Symbol: pck-1 Name: Phosphoenolpyruvate CarboxyKinase 1 Alias: PEPCK-1 Entrez gene ID: 175171 Ensembl gene ID: W05G11.6 Species: Worm (Taxid: 6239) Function: cytosolic form of phosphoenolpyruvate carboxykinase Observation: RNA interference of pck-1 during the adulthood significantly shortens lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pck-1 from hatching cases larval lethality. Overexpression of pck-1 greatly increases content of PEPCK-C, markedly induces enzyme activity and significantly increases mean, 75%ile, and maximum lifespan by 19-23%, 17-22%, and 21% [22810224]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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