Symbol: OSH7 Name: OxySterol binding protein Homolog 7 Entrez gene ID: 856389 Ensembl gene ID: YHR001W Species: Yeast (Taxid: 4932) Functional description: Osh6p; Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001711] [Ensembl] Observation: Overexpression of OSH7 extends mean replicative lifespan. PERG6-OSH7 does not extend the maximum lifespan significantly [Xia et al., unpublished]. Deletion of the CC domain of Osh7 (Perg6-OSH7-ORD) greatly shortens the lifespan. Deletion of the Osh7's CC domain decreases lifespan (Perg6-OSH7-ORD) shortens the lifespan [Tang et al., personal communication]. Osh7 interacts with the late endosome ATPase Vps4 by their C-terminal coiled-coil (CC) domain. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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