Symbol: abi-1 Name: ABl Interactor homolog Alias: ABl Interactor homolog family member (abi-1);WBGENE00015146 Entrez gene ID: 175789 Ensembl gene ID: B0336.6 Species: Worm (Taxid: 6239) Functional description: Protein ABI-1; ABl Interactor homolog family member (abi-1) [Source:RefSeq peptide;Acc:NP_498224] [Ensembl]; abi-1 encodes an Abl interactor orthologous to human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); abi-1 is required for epidermal cell migrations during embryonic enclosure and for proper migration of the excretory cell and mechanosensory and motoneurons; ABI-1 physically interacts with the N-terminus of UNC-53/NAV2, which may provide a link between ABI-1 and the ARP2/3 complex; ABI-1 also physically interacts with ABL-1, and is required for apoptotic cell engulfment and normal distal tip cell migration; ABI-1 is expressed in a number of head and nerve ring neurons including the amphid interneurons AIYL/R and the RMEL/R motoneurons, several types of ventral cord motoneurons and the coelomocytes; in neurons, ABI-1 localizes to the cell bodies, dendrites and commissural axons. [WormBase] Observation: abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit