arx-4

Symbol: arx-4
Name: ARp2/3 compleX component 4
Entrez gene ID: 175247
Ensembl gene ID: Y6D11A.2
Species: Worm (Taxid: 6239)

Functional description:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). [UniProt]

Observation:

RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689].



Interventions:
  • arx-4 RNAi -61%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ARPC2 (9606)
  • ARPC2 (9598)
  • ARPC2 (9615)
  • ARPC2 (9913)
  • Arpc2 (10090)
  • Arpc2 (10116)
  • ARPC2 (9031)
  • arpc2 (7955)
  • Arc-p34 (7227)
  • AgaP_AGAP009154 (7165)
  • arx-4 (6239)
  • arc2 (4896)
  • GeneID:2678068 (148305)
  • NCU03050 (5141)
  • DIS2 (3702)



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