Symbol: dcn-1 Name: Defective in Cullin Neddylation Alias: WBGene00010428 Entrez gene ID: 175556 Ensembl gene ID: H38K22.2 Species: Worm (Taxid: 6239) Functional description: Required for neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8- charged E2 enzyme to the cullin component of SCF-type complexes. [UniProt] Observation: snap-1 RNAi in the adulthood extends the lifespan [New longevity regulators] Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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