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Symbol: gpa2 Name: Guanine nucleotide-binding protein alpha-2 subunit Alias: git8 Entrez gene ID: 2541720 Ensembl gene ID: SPAC23H3.13c Species: (Taxid: 4896) Functional description: family with sequence similarity 49, member A [Source:HGNC Symbol;Acc:25373] [Ensembl] Observation: gpa2 (alias git8) encodes the alpha subunit of a heterotrimeric G protein, which acts downstream of Git3. Git8 activity accelerates aging and inhibits the lifespan-extending effect of DR. Constitutive active mutation of gpa2 decreases chronological lifespan under AL (2% glucose) and almost completely cancels out the lifespan extending effect of DR (0.2% glucose) [19266076]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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