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Symbol: LCB1 Name: Long Chain Base 1 Alias: END8;TSC2 Entrez gene ID: 855342 Ensembl gene ID: YMR296C Species: Yeast (Taxid: 4932) Functional description: Lcb1p; Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [Source:SGD;Acc:S000004911] [Ensembl] Observation: Downregulating LCB1 and LCB2, which encode subunits of serine palmitoyltransferase (SPT), the first rate-limiting enzyme in sphingolipid biosynthesis, increases chronological lifespan. Myriocin, an inhibitor of SPT increases chronological in a dose-dependent manner. Downregulation of LCB1 or myriocin treatment reduces LCBS and LCBPs [22319457]. Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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