Symbol: Sin3A Alias: CG8815-PA;CG8815-PB;CG8815-PC;CG8815-PD;CG8815-PE;CG8815-PF;Sin3A-PA;Sin3A-PB;Sin3A-PC;Sin3A-PD;Sin3A-PE;Sin3A-PF;enhancerofGMR-sina2-3 Entrez gene ID: 36382 Ensembl gene ID: FBgn0022764 Species: Fly (Taxid: 7227) Functional description: Scoffolding protein that complexes with histone deacteylases (HDAC1/2) where it interacts with corepressors to control transcriptional silencing of genes; CG8815 gene product from transcript CG8815-RC; Sin3A [Source:FlyBase gene name;Acc:FBgn0022764] [Ensembl]; The gene Sin3A is referred to in FlyBase by the symbol Dmel\Sin3A (CG8815, FBgn0022764). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; neuron development; regulation of mitotic cell cycle; muscle organ development; negative regulation of transcription, DNA-dependent. 60 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; mesothoracic tergum; mitochondrion; crystal cell. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Histone deacetylase interacting; Paired amphipathic helix. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [FlyBase] Observation: Overexpression of Sin3A increases mean and maximum lifespan by 13% and 3%, respectively [22366109]. Interventions: Assays: Organismal Lifespan Mean: +13 Maximum: +3 Classification: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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