|
Symbol: Nfkbia Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Entrez gene ID: 18035 Ensembl gene ID: ENSG000001 Species: Mouse (Taxid: 10090) Functional description: Inhibits NF-KappaB signaling; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. [UniProt] Observation: Overexpression of an endothelial dominant-negatvie I?B? gene prolonged the lifespan [22302838]. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
Comment on This Data Unit