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Symbol: ZDS2 Name: Zillion Different Screens 2 Entrez gene ID: 854931 Species: Yeast (Taxid: 4932) Functional description: Zds2p; Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p [Source:SGD;Acc:S000004577] [Ensembl]; Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p [SGD] Observation: Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670]. ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1-binding site in the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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