Denigma: Factor

Arhgap1

Symbol: Arhgap1
Name: Rho GTPase activating protein 1
Entrez gene ID: 228359
Ensembl gene ID: ENSMUSG00000027247
Species: Mouse (Taxid: 10090)

Functional description:
Regulation of actin cytoskeleton organization, polarity, and growth; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity). [UniProt]

Observation:

Most Ahrgap1 knockout mice are weak and die during the neonatal period. Animals that survived have a shorter lifespan (median lifespan is 12 months) and show premature aging-like phenotypes, including a reduction in body mass, a loss of subdermal adipose tissue, lordokyphosis, and osteoporosis [17227869].

Interventions:

Arhgap1 knockout

Assays: Organismal Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

17227869: Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.

Aging Relevance Analysis/Source:

GenAge