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Symbol: UMP1 Name: Short-lived chaperone required for correct maturation of the 20S proteasome; degraded by proteasome upon completion of its assembly; involved in ubiquitin-mediated proteolysis; mutant defective in degradation of short-lived proteins Alias: SON1;UFD5 Entrez gene ID: 852471 Ensembl gene ID: YBR173C Species: Yeast (Taxid: 4932) Functional description: Proteasome assembly protein; Ump1p; Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly [Source:SGD;Acc:S000000377] [Ensembl] Observation: Cells expressing elevated levels of Ump1 exhibited an enhanced preservation of proteasome-mediated protein degradation, and enhanced viability during stationary-phase aging [16337885]. Deletion of UMP1 reduces mean (-32%) and maximum (-7%) replicative lifespan [21931558]. Assays: Mean: -32 Maximum: -7 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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