Symbol: CDC25
Name: Cell Division Cycle 25
Alias: CTN1
Entrez gene ID: 851019
Ensembl gene ID: YLR310C
Species: Yeast
(Taxid: 4932)
Functional description:
Cdc25p; Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 [Source:SGD;Acc:S000004301] [Ensembl]
Observation:
The CDC25-10 allele extends mean and maximum replicative lifespan by 34% and 18%, respectively, at 30 degree Celsius. cdc25-10 mutants have an extended replicative lifespan under AL. Growth on 0.5% glucose restriction does not further extend replicative lifespan of cdc25-10 mutants. CDC25 null mutant is not viable. CDC25 appears to act in the same genetic pathway as SIR2 and NPT1 and is suggested to be genetic model of DR [11000115].
Interventions:
CDC25 mutation
+34%
+18%
Assays:
Replicative Lifespan
Mean: +34
Maximum: +18
Classification:
Gerontogene
Positive Gerontogene
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
CDC25
(4932)
KLLA0D09306g
(28985)
AGOS_ADL038W
(33169)
Orthologs
C3G
(7227)
Sos2
(10116)
Rapgef1
(10116)
RAPGEF1
(9544)
CG5522
(7227)
LOC100361774
(10116)
Ralgps1
(10090)
sos-1
(6239)
RALGPS2
(9544)
RALGPS1
(9606)
Ralgps2
(10090)
SOS1
(9544)
Sos1
(10090)
Sos2
(10090)
Y34B4A.4
(6239)
Sos1
(10116)
RAPGEF1
(9606)
Rapgef1
(10090)
Sos
(7227)
SOS2
(9544)
RALGPS2
(9544)
Ralgps2
(10116)
RALGPS2
(9606)
SOS1
(9606)
SOS2
(9606)
C3G
(7227)
Sos2
(10116)
Rapgef1
(10116)
RAPGEF1
(9544)
CG5522
(7227)
LOC100361774
(10116)
Ralgps1
(10090)
sos-1
(6239)
RALGPS2
(9544)
RALGPS1
(9606)
Ralgps2
(10090)
SOS1
(9544)
Sos1
(10090)
Sos2
(10090)
Y34B4A.4
(6239)
Sos1
(10116)
RAPGEF1
(9606)
Rapgef1
(10090)
Sos
(7227)
SOS2
(9544)
RALGPS2
(9544)
Ralgps2
(10116)
RALGPS2
(9606)
SOS1
(9606)
SOS2
(9606)
C3G
(7227)
Sos2
(10116)
Rapgef1
(10116)
RAPGEF1
(9544)
CG5522
(7227)
LOC100361774
(10116)
Ralgps1
(10090)
sos-1
(6239)
RALGPS2
(9544)
RALGPS1
(9606)
Ralgps2
(10090)
SOS1
(9544)
Sos1
(10090)
Sos2
(10090)
Y34B4A.4
(6239)
Sos1
(10116)
RAPGEF1
(9606)
Rapgef1
(10090)
Sos
(7227)
SOS2
(9544)
RALGPS2
(9544)
Ralgps2
(10116)
RALGPS2
(9606)
SOS1
(9606)
SOS2
(9606)
Edit \
Update
(Admin) |
Delete
|
|
Comment on This Data Unit