| Collaborative Knowledge-Management | 1 | 2 | Kulaga; Wuttke | We will establish **new kind of collaboration models** between people (including Researches) and in **Graph representation of knowledge**.
``Collaboration and knowledge-management websystems`` are the clue that **increases collective intelligence*... |
| Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
| Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
| Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
| Aging Reprogramming | 0 | 3 | Stolzing; Wuttke; Johnson |
:Abstract: Ectopic expression of defined pluripotence-associated Factors reprograms adult somatic cells back to an Embryonic Stem Cell-like state. During this process the phenoytpic characteristics of Aging are also reverted. Cells can even be di... |
| miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
| Tissue-Specific DR-Effects | 2 | 4 | Kapahi; Magalhaes; Wuttke; Li |
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Circadian Clock Controls Ageing | 2 | 3 | Magalhaes; Wuttke; Wood |
:Abstract: Dietary restriction without malnutrition delays ageing and extends lifespan, but the molecular mechanism is still unknown. Ageing gene expression changes originate from development and growth cessation, are modulated by diet, and manip... |
| Long-Lived Species | 1 | 8 | Hudson; Penzias; Lee; Lee; Lee; Johnson; Hsu; Dodd |
:Abstract: Wonders of extraordinary long-lived species - will they ever end? Species adapted to their environments with a specific lifespan. Most species developed aging to speed up their evolution. Non-aging species normally would be out-compete... |
| in situ Regeneration | 1 | 2 | Wuttke; Zamani |
:Abstract: As we are young everything regenerates perfectly. In fact, our body harbors the plan to reconstruct itself from scratch which is localized in the nucleus of each of our body cells. However, as we grow up our regenerative capacities decre... |
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