Authors: Rives AW; Galitski T
Abstract: We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.
Keywords: *Cell Communication; Cluster Analysis; Databases as Topic; Fungal Proteins/*metabolism; *Signal Transduction; Software
Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 100 Issue: 3 Pages: 1128-33 Date: Jan. 23, 2003 PMID: 12538875 |
Network
Rives AW, Galitski T (2003) Modular organization of cellular networks. Proceedings of the National Academy of Sciences of the United States of America 100: 1128-33.
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