Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
22 | D-3-hydroxybutyrate increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
23 | D-3-hydroxybutyrate increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
64 | Decrease in WNT gene expression | 9606 | RoSyBa 2011 | — | adipose-derived stem cells | age | 40 year | 60 year | females | A dramtic decrease in WNT gene expression occurs in Adipose-dreived stem cells from females at the age of 40-60 years [RoSyBa 2011]. |
99 | Decreased body fat | 10090 | — | — | — | Diet | DR | AL | — | Body fat decreases upon DR [6608731]. |
103 | Decreased stem cell activity | — | — | 20504968 | — | age | — | — | — | Advanced age is associated with decreased stem cell activity [20504968]. |
59 | Deteriorarition of circadian rhytms | 10090 | Farajnia, et al 2012 | — | Suprachiasmatic Nucleus | age | 2 month | 30 month | — | Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuronâs rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm. |
46 | DHEA declines | 9606 | Jeff | — | — | — | 70 | — | male | — |
52 | DHEA decreases | 9606 | Hinson and Raven, 1999 | 10495400 | serum | age | 25 year | 85 year | males/females | DHEAS (Dehydroepiandrosterone sulphate) is the most abundant circulating steroid secreted by adrenal glands. Duo to its position int the steroid cascade DHEA act like kind of âthe mother steroidâ (Regelson et al., 1994). DHEA reaches its highest levels at age 20-24. Its serum concentration declines with increasing age after 25 years and diminishes about 95% by 85 years. DHEA deficiency syndrome is a new term for old age [10495400]. |
54 | DHEA decreases | 9544 | Lane et al., 1997 | 9215277 | serum | Age | 5 year | 26 year | males/females | Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277]. |
55 | DHEA deline slows | 9544 | Lane et al., 199 | 9215277 | serum | diet | DR | — | males/females | DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277]. |
51 | DHEA increases | 9606 | Willcox et al., 2007 | 17986602 | serum | diet | Okinawa | — | — | Okinawa aged 65-plus have relatively high DHEA levels. |
53 | DHEA increases | 9606 | Hinson and Raven, 1999 | 10495400 | serum | age | 10 year | 20 year | males/females | DHEA reaches its highest levels at age 20-24 [10495400]. |
97 | Diminished cognitive skills | 9606 | — | — | — | age | — | — | — | Cognitive skill such as learning and memory diminish with age [http://www.sciencedaily.com/releases/2012/06/120629211902.htm]. |
2 | Downregulation of exo-3 | 6239 | Schlotterer et al., 2010 | 20346071 | Whole body | Age | — | — | — | — |
126 | Elevated long-chain lactosylceramides | 9606 | — | 21687659 | fibroblasts | age | old | young | — | Long-chain lactosylceramides (LacCers) are significantly elevated in human fibroblasts isolated from elderly individuals [21687659]. |
83 | elt-3 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-3 increases during devleopment and aging [17608836]. |
81 | elt-5 expression increases | 6239 | 17608836 | 17608836 | — | age | — | — | — | Expression of elt-5 increases with during devleopment and aging [17608836]. |
82 | elt-6 expression increases | 6239 | — | 17608836 | — | age | — | — | — | Expression of elt-6 increases during devleopment and aging [17608836]. |
101 | Enhanced mitochondrial function | 7227 | Zid et al. 2009 | 19804760 | — | diet | DR | AL | — | Flies upon DR have enhanced mitochondrial function, which is mediated by enhanced mRNA translation of nuclear-encoded mitochondrial mRNAs in a d4E-BP dependent manner [19804760] |
105 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
112 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Eno1 levels [Herbert et al. in press]. |
113 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
114 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
62 | Fertility declines | 6239 | — | 20041217 | whole body | age | — | — | females | Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217]. |
63 | Fertility declines | 9606 | 20041217 | — | whole body | age | — | — | females | Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217]. |
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