Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
85 | Cell proliferation decreases | 10116 | — | 11744049 | — | Diet | — | — | — | 24 month DR in rats inhibits cell proliferation in glandular stomach and liver tissue [11744049]. |
87 | LysoPC(16:1) decrease | 10090 | — | 22661299 | — | — | 3 months | 12 momths | — | Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299]. |
88 | Structural chromosome variation | 9606 | — | — | — | — | — | — | — | Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012]. |
89 | Chromosomal anomalies | 969 | — | — | — | age | — | — | — | Chromosomal anomalies (rearrangements and aneuploidies) during cell division increases with age in cultured lymphocytes and fibroblasts [30,31 in Lauri et al. 2012]. |
90 | Accumulation of DNA damage | 10090 | — | — | — | age | — | — | — | DNA damage accumulates with age in mouse hematopoietic stem cells [32 in Lauri et al. 2012]. |
95 | Ceramides increase | — | — | — | — | age | — | — | — | Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012]. |
96 | Loss of histone proteins from the genome | 4932 | — | 20832724 | — | age | — | — | — | Normal aging is accompanied by a profound loss of histone proteins from the genome [20832724]. |
97 | Diminished cognitive skills | 9606 | — | — | — | age | — | — | — | Cognitive skill such as learning and memory diminish with age [http://www.sciencedaily.com/releases/2012/06/120629211902.htm]. |
99 | Decreased body fat | 10090 | — | — | — | Diet | DR | AL | — | Body fat decreases upon DR [6608731]. |
101 | Enhanced mitochondrial function | 7227 | Zid et al. 2009 | 19804760 | — | diet | DR | AL | — | Flies upon DR have enhanced mitochondrial function, which is mediated by enhanced mRNA translation of nuclear-encoded mitochondrial mRNAs in a d4E-BP dependent manner [19804760] |
102 | Increased fat synthesis and oxidation | 10090 | — | — | — | diet | DR | AL | — | During DR there is an increased fat synthesis and oxidation [19887594]. |
103 | Decreased stem cell activity | — | — | 20504968 | — | age | — | — | — | Advanced age is associated with decreased stem cell activity [20504968]. |
104 | Hsp12 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hsp12 levels [Herbert et al. in press]. |
105 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
106 | Hxk1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hxk1 levels [Herbert et al. in press]. |
107 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Rtc3 levels [Herbert et al. in press]. |
108 | Rgil induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
109 | Sbp1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Sbp1 levels [Herbert et al. in press]. |
110 | Yef3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Yef3 levels [Herbert et al. in press]. |
111 | Ctt1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Ctt1 levels [Herbert et al. in press]. |
112 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Eno1 levels [Herbert et al. in press]. |
113 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
114 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
115 | Hsp26 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp26 levels [Herbert et al. in press]. |
116 | Hsp31 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp31 levels [Herbert et al. in press]. |
Comment on This Data Unit