Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
1 ROS production increases 4932 Laun et al., 2001 11251834 Age young old
2 Downregulation of exo-3 6239 Schlotterer et al., 2010 20346071 Whole body Age
3 HDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
4 HDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
5 HDL increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
6 VLDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
7 VLDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
8 VLDL decrease 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
9 LDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
10 LDL decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
11 Valine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
12 Isoleucine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
13 Lactate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
14 2-hydroxyisobutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
15 Acetate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
16 N-acetyl glycoprotein decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
17 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
18 N-acetyl glycoprotein increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
19 Methionine decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
20 Methionine increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
21 Acetoacetate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
22 D-3-hydroxybutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
23 D-3-hydroxybutyrate increases 10090 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1df/df at 16 weeks male
24 Citrate decreases 10090 Wijeyesekera et al., 2012 22225495 Plasma Diet 30% DR for 48h at 16 weeks male
25 Citrate increases 10099 Wijeyesekera et al., 2012 22225495 Plasma Mutant Irs1-/- at 16 weeks male
  • Page 1 of 6
  • 25 of 129 Biological changes

Add change

Comment on This Data Unit


Please log in for making a comment without the need to specify any credentials.