Oncogene-Induced Senescence

Created on Dec. 14, 2012, 11:13 p.m. by Hevok & updated by Hevok on May 2, 2013, 4:56 p.m.

Activated oncogenes are able to induce senescence The intrinsic processes required for the induction of oncogene-induced senescence is the cellular response to DNA damage. In many types of cells, oncogene-induced senescence depends on induction of DNA damage response. DNA damage, at least partially originates from under-expression of key enzymes involved in deoxyribonucleoside biosynthesis and subsequent depletion of endogenous deoxyribonucleoside triphosphate (dNTP) pools. Even partial restoration of depleted intracellular dNTP pools is sufficient for substantial suppression of DNA damage and senescence [http://www.biocompare.com/Life-Science-News/127227-Previously-Unknown-Mechanism-Identified-In-Oncogene-Induced-Senescence/].


Tags: DNA damage, aging, oncogenes, senesence, nucleotides
Parent: Cellular Senescence

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