Authors: Saul N; Pietsch K; Menzel R; Steinberg CE
Abstract: The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
Keywords: Animals; Antioxidants/*pharmacology; Caenorhabditis elegans; Caenorhabditis elegans Proteins/*genetics/*physiology; Dose-Response Relationship, Drug; Gene Expression Profiling; Longevity/drug effects/*genetics; *Mutation; Oxidative Stress; Quercetin/*pharmacology; Temperature; Time Factors; Transcription Factors/*genetics/*physiology
Journal: Mechanisms of ageing and development Volume: 129 Issue: 10 Pages: 611-3 Date: Aug. 12, 2008 PMID: 18692520 |
Saul N, Pietsch K, Menzel R, Steinberg CE (2008) Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved? Mechanisms of ageing and development 129: 611-3.
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