Polymorphism: BRCA1 haplotypes
Variant Type: Haplotype
Location: 17q21
Factor:
- Symbol: BRCA1
- Name: breast cancer 1, early onset
- Entrez ID: 672
- Ensembl ID: ENSG00000012048
Factors:
BRCA1
breast cancer 1, early onset
(
672
/
ENSG00000012048
)
Description:
Initial results obtained with two-dimensional gene scanning (TDGS) suggest differences in BRCA1 genotype frequencies between the centenarian populations and controls.
Ethnicity:
New England American,
Italian
Age of cases: >100
Shorter lived allele: b
Finding: Negative
Statistics
- Number of cases/controls: 102 vs 97 (initial)
| 82 vs 97 (replication)
- Significant: No
Study Design
- Study type: Candidate Region/Gene
- Technology: Two-dimensional gene scanning (TDGS)
Reference:
11795532: BRCA1 gene sequence variation in centenarians.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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