Table 1: Osh proteins, their interaction association with lifespan factors and their homologs. For each Osh protein, the lifespan-determining interaction partners (both those that increase and those that decrease the lifespan if manipulated) out of all interactors were counted. Interactions were either of physical or genetic nature. From this a cumulative binomial p-value was calculated to estimate the significance of interacting with lifespan factors and therefore the likelihood to also impact on lifespan if altered (guilt by association concept). Osh proteins with a p-value less than 0.05 were considered to be likely also to affect the lifespan (in italic). The effect of over-expression (OE) of the respective gene for an Osh protein is indicated if determined (NA = not available). The closest homologs in nematode, fruit fly and man are listed.
Protein Interactions OE lifespan Homologs
Specific Total p-value Worm Fly Human
Osh1 (SWH1) 19 105 0.115 NA obr-1 obr-2 obr-3 Osbp CG3860 CG42668 OSBP OSBPL2 OSBP2
Osh2 (OSH2) 11 120 0.945 NA obr-1 obr-2 obr-3 CG3860 Osbp Osbp OSBP2 OSBP OSBPL2
Osh3 (OSH3) 14 64 0.045 NA obr-2 obr-1 obr-3 CG3860 CG42668 CG1513 OSBPL7 OSBPL3 OSBPL6
Osh4 (KES1) 26 167 0.254 NA obr-4 obr-3 obr-2 CG1513 CG42668 CG3860 OSBPL9 OSBPL5 OSBPL10
Osh5 (HES1) 3 32 0.829 Short obr-4 obr-3 obr-2 CG1513 CG42668 CG3860 OSBPL9 OSBPL11 OSBPL5
Osh6 (OSH6) 11 39 0.012 Long obr-3 obr-4 obr-2 CG42668 CG1513 CG3860 OSBPL5 OSBPL8 OSBPL9
Osh7 (OSH7) 21 77 0.011 NA obr-3 obr-4 obr-2 CG42668 CG1513 CG3860 OSBPL5 OSBPL9 OSBPL8
