Search by variant, gene, study or associated filed (example: ADRB2)
Search by Gene Ontology term (example: insulin)
polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs7803143 | PSCD3 | — | 1.57e-05 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | C | T | Genome-Wide Association Study | 22445811 |
rs7952321 | OR5AS1 | — | 4.68e-05 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | T | G | Genome-Wide Association Study | 22445811 |
rs978739 | TAS2R16 | 0.62 | 0.001 | 348 vs 593 | — | Calabrian | Mean age 93.82 | non-AA | AA | Candidate Region/Gene | 23133589 |
rs987839 | SLCO1B1 | — | 3.19e-06 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | T | C | Genome-Wide Association Study | 22445811 |
SLC6A4 | SLC6A4 | — | 1.0 | 224 vs 441 | — | Ashkenazi Jewish | 75 | — | — | Candidate Region/Gene | 15621215 |
(+)2019 del | ADIPOQ10 | — | 0.05 | 118 centenarians vs 78 unrelated young | — | Ashkenazi Jewish | 95-105 | A | Del/Del | Candidate Region/Gene | 18511746 |
(A/C)−110 | HSP70-1 | 0.40 | 0.005 | 120 vs 471 | — | Italian | 100 years and above | A | — | Candidate Region/Gene | 14501185 |
(HLA)-A1, B8, DR3 | — | — | 1.0 | 93 vs 100 | — | Irish | 80-97 years | — | — | Candidate Region/Gene | 12714268 |
(rs429358, rs7412) + (rs2075650) | APOE + TOMM40 | 0.93 | 0.337 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | e4 + G | — | Genome-Wide Association Study | 21418511 |
- | TH | — | 0.045 | 202 vs 170 vs 82 | — | Italian | 100-105 (oldest of 3 age groups, see notes) | — | — | Candidate Region/Gene | 11053670 |
- | Insulin signaling pathway (IIS) | — | 0.01 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
- | Telomere maintenance pathway (TM) | — | 0.02 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
- | GSTM1 | — | 0.54 | 66 vs 150 | — | Italian | 100.19±2.2 (95-105) | — | — | Candidate Region/Gene | 15195682 |
- | HRAS1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | 1 (specifically for SIRT3 in a French population) | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | SIRT3 | — | 0.145 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | TH | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | INS | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | IGF2 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | CYP1A | — | 0.68 | 94 vs 418 | — | Italian | 100 years vs 46 years | — | — | Candidate Region/Gene | 11162685 |
- | GSTM1 | — | 0.74 | 94 vs 418 | — | Italian | 100 years vs 46 years | — | — | - | 11162685 |
- | PARP1 | — | 1.0 | 239 vs 198 | — | French | >100 | — | — | Candidate Region/Gene | 9587069 |
- | F5 | — | 0.045 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | A | — | Candidate Region/Gene | 15621215 |
- | APOC1 | — | 0.05 | 282 vs 200 | — | British | 84 and over | — | — | Candidate Region/Gene | 9105559 |
--1082G-->A | IL10 | — | 0.0001 | 109 (oldest old men) vs 263 (healthy controls) | — | Italian | >95 | A | — | Candidate Region/Gene | 15466015 |
-1377G/A | FAS | — | 0.106 | 50 vs 86 | — | Italian | 100.8 ± 1.8 (100 to 106) | — | — | Candidate Region/Gene | 11965496 |