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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs7803143 PSCD3 1.57e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
rs7952321 OR5AS1 4.68e-05 1364 American, British Age range 50-108; mean age at death 80.2 T G Genome-Wide Association Study 22445811
rs978739 TAS2R16 0.62 0.001 348 vs 593 Calabrian Mean age 93.82 non-AA AA Candidate Region/Gene 23133589
rs987839 SLCO1B1 3.19e-06 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
(+)2019 del ADIPOQ10 0.05 118 centenarians vs 78 unrelated young Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
(A/C)−110 HSP70-1 0.40 0.005 120 vs 471 Italian 100 years and above A Candidate Region/Gene 14501185
(HLA)-A1, B8, DR3 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
(rs429358, rs7412) + (rs2075650) APOE + TOMM40 0.93 0.337 403 vs 1670 3746 vs 5912 Dutch Mean age 94 e4 + G Genome-Wide Association Study 21418511
- TH 0.045 202 vs 170 vs 82 Italian 100-105 (oldest of 3 age groups, see notes) Candidate Region/Gene 11053670
- Insulin signaling pathway (IIS) 0.01 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
- Telomere maintenance pathway (TM) 0.02 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
- GSTM1 0.54 66 vs 150 Italian 100.19±2.2 (95-105) Candidate Region/Gene 15195682
- HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
- SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- CYP1A 0.68 94 vs 418 Italian 100 years vs 46 years Candidate Region/Gene 11162685
- GSTM1 0.74 94 vs 418 Italian 100 years vs 46 years - 11162685
- PARP1 1.0 239 vs 198 French >100 Candidate Region/Gene 9587069
- F5 0.045 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 A Candidate Region/Gene 15621215
- APOC1 0.05 282 vs 200 British 84 and over Candidate Region/Gene 9105559
--1082G-->A IL10 0.0001 109 (oldest old men) vs 263 (healthy controls) Italian >95 A Candidate Region/Gene 15466015
-1377G/A FAS 0.106 50 vs 86 Italian 100.8 ± 1.8 (100 to 106) Candidate Region/Gene 11965496