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| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| rs11571461 | RAD52 | 2.23 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | G | Candidate Region/Gene | 22406557 |
| rs1383582 | Intergenic | 2.21 | 2.46e-05 | 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) | Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project | American | — | A | — | Genome-Wide Association Study | 21782286 |
| rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
| rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
| rs8052394 | MT1a | 2.16 | 0.0002 | 151 vs 100 | — | Italian | Mean age 91.4 +/- 4.1 | — | A | Candidate Region/Gene | 16955215 |
| rs268300 | Intergenic | 2.13 | 4.05e-05 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | — | A | Genome-Wide Association Study | 21418511 |
| rs671 | ALDH2 (for males) | 2.11 | 0.009 | 137 vs 213 | — | Korean | Mean age 90 | — | A | Genome-Wide Association Study | 19641380 |
| rs1980042 | LYN (for males) | 2.10 | 0.006 | 137 vs 213 | — | Korean | Mean age 90 | — | C | Genome-Wide Association Study | 19641380 |
| rs1979128 | — | 2.10 | 0.006 | 137 vs 213 | — | Korean | Mean age 90 | — | G | Genome-Wide Association Study | 19641380 |
| rs4746720 | SIRT1 | 2.10 | 0.0001 | 223 vs 277 | — | Chinese | Average age 93 | CC, TT | CT | Candidate Region/Gene | 23450480 |
| rs964403 | SUMF1 | 2.07 | 4.91e-05 | 410 vs 553 | — | Italian | 90–109 | — | — | Genome-Wide Association Study | 21612516 |
| rs3864051 | SUMF1 | 2.07 | 5.49e-05 | 410 vs 553 | — | Italian | 90–109 | — | — | Genome-Wide Association Study | 21612516 |
| rs1893132 | Intergenic | 2.07 | 3.19e-06 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | — | A | Genome-Wide Association Study | 21418511 |
| rs1805097 | IRS2 | 2.07 | 0.04 | 144 vs 418 | — | Caucasian | 85 to 104, mean age = 96 ± 4 | C | — | Candidate Region/Gene | 19887537 |
| rs2075650 | TOMM40 | 2.07 | 2.36e-10 | 801 vs 914 | 253 vs 341 | Caucasian | Median age 104 | G | A | Genome-Wide Association Study | 22279548 |
| rs4505466 | SH3BP4 | 2.06 | 8.31e-05 | 410 vs 553 | — | Italian | 90–109 | — | — | Genome-Wide Association Study | 21612516 |
| HLA-DRB1 13 generic DRB1 alleles | HLA-DRB1 | 2.03 | 0.001 | 336 vs 2950 | 208 vs original 2950 | French | 100+ and 90+ siblings | non-DR11 alleles | DR11 | Candidate Region/Gene | 9425225 |
| rs1805097 | IRS2 | 2.03 | 0.0003 | 144 vs 418 | — | Italian | 85-100 years old | non-AA | AA | Candidate Region/Gene | 19887537 |
| rs1887922 | IDE | 2.02 | 0.0004 | 829 vs 1033 | — | Australian, Caucasian | Mixed | — | — | Candidate Region/Gene | 18448515 |
| mtDNA haplogroups | mtDNA | 2.01 | 0.003 | 367 vs 371 | — | Chinese | Mean age 94.4 | non-F | F | Mitochondrial Haplogroup | 21945877 |
| rs4777170 | — | 2.00 | 4.52e-05 | 410 vs 553 | — | Italian | 90–109 | — | — | Genome-Wide Association Study | 21612516 |
| APOE e2/e4 | APOE | 2.00 | 0.001 | 300 vs 160 | — | French | 100+ | e4 | e2 | Candidate Region/Gene | 8136829 |
| rs2290889 | SYK | 2.00 | 9.14e-06 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | — | A | Genome-Wide Association Study | 21418511 |
| rs7864625 | SYK | 2.00 | 1.01e-05 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | — | G | Genome-Wide Association Study | 21418511 |
| rs3211994 | NTHL1 | 1.99 | 0.0056 | 1089 vs 736 | 1613 vs 1104 | Danish | 92.2–93.8 (mean age 93.2) | G | — | Candidate Region/Gene | 22406557 |
