Symbol: Hsp70Ba
Name: Heat-shock-protein-70Ba
Entrez gene ID: 44921
Ensembl gene ID: FBgn0013277
Species: Fly
(Taxid: 7227)
Observation:
Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% [19420297].
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762].
Interventions:
Trichostatin A supplementation
+25%
Hsp70Ba overexpression
-30%
-30%
Assays:
Chronological Lifespan
Mean: -30
Maximum: -30
Classification:
Longevity-Associated
Longevity-Induced
Type:
Gene
Protein coding
References:
19420297: Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.
15695762: Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
HSPA1A
(9606)
HSPA1B
(9606)
HSP70
(9615)
HSPA1A
(9913)
Hspa1b
(10090)
Hspa1a
(10090)
Hspa1b
(10116)
LOC100333726
(7955)
Hsp70Ab
(7227)
Hsp68
(7227)
Hsp70Aa
(7227)
Hsp70Bc
(7227)
Hsp70Ba
(7227)
Hsp70Bb
(7227)
Hsp70Bbb
(7227)
SSA3
(4932)
KLLA0E20527g
(28985)
AGOS_AER187W
(33169)
AT3G09440
(3702)
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