Polymorphism: -
Location: 11p15.5
Factor:
- Symbol: TH
- Name: tyrosine hydroxylase
- Entrez ID: 7054
- Ensembl ID: ENSG00000180176
Factors:
TH
tyrosine hydroxylase
(
7054
/
ENSG00000180176
)
Description:
The study checked for non-random associations between mtDNA haplotypes and nuclear polymorphisms in long-lived individuals_x000D_. There wasn't cases vs control, but stratification to 3 age groups.mtDNA haplogroup and TH genptype were assigned following procedures described in De Benedictis et al., 1999 and in De Benedictis et al., 1998, respectively.
Ethnicity:
Italian
Age of cases: 100-105 (oldest of 3 age groups, see notes)
Statistics
- Number of cases/controls: 202 vs 170 vs 82 (initial)
- p-value:
0.045
[0.045]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: N/A
Reference:
11053670: Does a retrograde response in human aging and longevity exist?
Choice: Curate
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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