Denigma Buck Institute Health Extension
Polymorphism: HLA-DRB1 haplotypes



Location: 6p21.3

Factor:
- Symbol: HLA-DRB1
- Name: major histocompatibility complex, class II, DR beta 1
- Entrez ID: 3123
- Ensembl ID: ENSG00000196126

Factors:
  • HLA-DRB1 major histocompatibility complex, class II, DR beta 1 ( 3123 / ENSG00000196126 )


    • Description:

    "... only a positive association with DRB11401 [longer-lived allele] was statistically significant even after the corrected P value test..." Alleles that were significant before but not after corrected P value test: Increased in centenarians (HLA-DRB10101, HLA-DRB11201); Decreased in centenarians (HLA-DRB10403, HLA-DRB1*1302)

    odds_ratio = RR = 4.146 (could not convert string to float: RR = 4.146)

    Ethnicity: Okinawan
    Age of cases: Mean age 102.3 +/- 1.9 years
    Shorter lived allele: non-DRB1*0401 alleles
    Longer lived allele: DRB1*0401

    Statistics
    - Number of cases/controls: 120 vs 129 (initial)
    - p-value: 0.004 [0.004]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology:

    Reference:
    9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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