Denigma Buck Institute Health Extension
Polymorphism: G477T


Location: 11p15.5

Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082

Factors:
  • SIRT3 sirtuin 3 ( 23410 / ENSG00000142082 )


    • Description:

    Only significant in males. TT increased with age (P=0.272), GT decreased (P=0.0391).

    Ethnicity: Italian
    Age of cases: 120 subject aged 100 or older
    Shorter lived allele: GT
    Longer lived allele: TT

    Statistics
    - Number of cases/controls: 801 (initial)
    - p-value: 0.0272 [0.0272]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    14580859: Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:06 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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