Denigma Buck Institute Health Extension
Polymorphism: −675 4G/5G



Location: 7q22.1

Factor:
- Symbol: PAI1
- Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Entrez ID: 5054
- Ensembl ID: ENSG00000106366

Factors:
  • PAI1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 ( 5054 / ENSG00000106366 )


    • Description:

    PAI-1 4G/4G genotype appeared to be associated with lower non-cardiovascular mortality in men, but with greater cardiovascular mortality in women. Detailed OR information is as follows:

    Ethnicity: American, Caucasian
    Age of cases: 65+
    Shorter lived allele: 5G (men)
    Finding: Positive

    Statistics
    - Number of cases/controls: 2224 (initial)
    - Odds ratio: 0.81
    - p-value: 0.04
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: N/A

    Reference:
    15939070: Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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