Polymorphism: rs429358, rs7412
rs429358,
(
SNPedia |
23andMe
)
rs7412
(
SNPedia |
23andMe
)
Variant Type: Haplotype
Location: 19q13.2
Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203
Factors:
APOE
apolipoprotein E
(
348
/
ENSG00000130203
)
Description:
Summary: aged persons vs younger (+ vs extremely young). rs5128 differs at barely significant level between centenerians and one of young control group.
pvalue = <0.001 (e4), <0.01 (others)
Ethnicity:
Finn
Age of cases: Mean age 100
Shorter lived allele: e4
Longer lived allele: e2, e3
Finding: Positive
Statistics
- Number of cases/controls: 179 vs 615 (initial)
- p-value:
0.001
[<0.001 (e4), <0.01 (others)]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
8018664: Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.
Choice: Curate
Created: July 2, 2013, 2:54 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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