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Longevity DB
Genetic variants implicated in human longevity.
Polymorphism:
rs10194564
rs10194564
(
SNPedia
|
23andMe
)
Location:
2q21.2
Factor:
- Symbol:
Intergenic (upstream of LRP1B)
- Name:
low density lipoprotein receptor-related protein 1B
- Entrez ID:
53353
- Ensembl ID:
ENSG00000168702
Factors:
Intergenic (upstream of LRP1B)
low density lipoprotein receptor-related protein 1B
(
53353
/
ENSG00000168702
)
Ethnicity:
Dutch
Age of cases:
Mean age 94
Longer lived allele:
A
Statistics
- Number of cases/controls:
403 vs 1670 (initial)
|
3746 vs 5912 (replication)
- Odds ratio:
1.55
- p-value:
8.88e-05 [8.88x10^-5]
- Significant:
Yes
Study Design
- Classifications:
Longevity-Associated
- Study type:
Genome-Wide Association Study
- Technology:
Illumina Infinium HD Human660W-Quad BeadChips; Illumina Infinium II HumanHap550-Duo BeadChips
Reference:
21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Choice:
Curate
Created:
July 2, 2013, 2:54 a.m.
Updated:
Aug. 8, 2014, 1:05 p.m.
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