Polymorphism: rs1042718-rs1042719
rs1042718-rs1042719
(
SNPedia |
23andMe
)
Variant Type: Haplotype
Location: 5q31-q32
Factor:
- Symbol: ADRB2
- Name: adrenergic, beta-2-, receptor, surface
- Entrez ID: 154
- Ensembl ID: ENSG00000169252
Factors:
ADRB2
adrenergic, beta-2-, receptor, surface
(
154
/
ENSG00000169252
)
Description:
LD of rs1042718 & rs1042719
Ethnicity:
Chinese
Age of cases: Mean age 102.1±0.20
Shorter lived allele: G-C
Longer lived allele: A-C
Finding: Positive
Statistics
- Number of cases/controls: 384 vs 384 (initial)
| 579 vs 644 (replication)
- Odds ratio: 0.63
- p-value:
1.86e-05
[1.86E-05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Protocol of BigDye v1.1 kit and an ABI 3130XL sequencing system (Applied Biosystems)
Reference:
23020224: Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.
Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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