Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2229765 IGF-1 — 0.04 222 vs 288 — Italian >85 G A Candidate Region/Gene 19460140
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs1800591-rs61733139 MTTP — 0.61 197 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs1800591 MTTP — 0.6 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs61733139 MTTP — 0.57 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
rs12050077 TSHR 1.32 0.01 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
rs10149689 TSHR 1.22 0.08 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
DRD4 7R allele DRD4 — 3.5e-08 310 vs 2909 — European mean age 95.2 years — — Candidate Region/Gene 23283341
rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
ACE genotype ACE — 0.716 102 vs 7232 — Korean Mean age 102 — — Candidate Region/Gene 12634288
rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
rs28969505 YTHDF2 — 0.047 136 vs 275 — Italian Mean age 101 — 15-15 (205 bp) Candidate Region/Gene 16799135
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
E4 APOE — 0.013 35 vs 125 — Chinese 90 years or over — — Candidate Region/Gene 11780357