Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
1376G/T;1388G/A;95A/G;871G/A;1024C/T;1360C/T;392 G/T G6PD 6.30 0.013 173 total (see notes) — Chinese >80 — — Candidate Region/Gene 17077204
5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
APOB XbaI − SI000565Q APOB — 0.006 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
E4 APOE — 0.013 35 vs 125 — Chinese 90 years or over — — Candidate Region/Gene 11780357
FOXO3A, various FOXO3 1.67 0.0002 760 vs 1060 — Chinese 100+ — — Candidate Region/Gene 20884733
Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 — Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 — Chinese >93 Cw3, Cw6. Cw7 — Candidate Region/Gene 9147371
microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 — 0.922 493 vs 425 — Chinese (females ≥ 94; males ≥ 90 — — Candidate Region/Gene 20199671
mt5178A ND2 — 0.05 95 vs 105 — Chinese Mean age 76 — АА Candidate Region/Gene 12384792
mtDNA C150T — — 0.936 556 vs 403 — Chinese 90–108 (94.59±3.34) — — Candidate Region/Gene 21262335
rs1042713 ADRB2 — 0.149 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
rs1042714 ADRB2 — 0.558 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
rs1061581 HSPA1B — 0.05 191 vs 53 — Chinese >90 A G Candidate Region/Gene 19840767
rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
rs11279109 - APOB XbaI APOB — 0.001 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 — D - X+ Candidate Region/Gene 17393087
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