Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
rs1799752 ACE — 0.016 12 vs 190 vs 105 — Greek 99-111 D I Candidate Region/Gene 23389097
rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
T-455C APOC3 — 0.005 183 vs 110 — Russian 70-106 T C Candidate Region/Gene 11193221
ACE D/I ACE — 0.02 689 — Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
rs507879 CASP5 — 1.4e-05 510 vs 549 — Russian 75–103 AG AA, GG Candidate Region/Gene 20434535
rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
rs1800795 IL-6 — 0.018 285 — Finn 90-95 C G Candidate Region/Gene 15664628
rs1800871 IL-10 — 0.0026 500 — Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
G477T SIRT3 — 0.0272 801 — Italian 120 subject aged 100 or older GT TT Candidate Region/Gene 14580859
HFE C282Y HFE — 7.2e-07 35 vs 106 — 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
rs1800896 IL10 — 0.019 174 vs 227 — Italian >100 — GG Candidate Region/Gene 12676903
rs2866164 MTP — 0.05 205 vs 288 — Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
APOE polymorphism APOE — 0.0001 291 vs 589 — Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
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