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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
African European (1)
Australian (3)
Canadian (1)
Finn (14)
Georgian (4)
Human (3)
Sichuan (18)
Spanish (4)
American (46)
African American (2)
Mexican (1)
Tunisian (1)
Turkish (3)
Asian (1)
Chinese (70)
Japanese (59)
Okinawan (4)
Korean (1)
Brazilian (2)
Caucasian (82)
European (4)
British (20)
Polish (14)
Croatian (1)
Danish (83)
Dutch (16)
French (17)
German (102)
Greek (9)
Irish (15)
Italian (180)
Calabrian (1)
Calabrian (8)
Bulgarian (7)
Swiss (1)
Spaniard (10)
Hispanic (1)
Ashkenazi Jewish (36)
Jordanian (8)
Russian (4)
Tatar (1)
Study type:
+
-
Candidate Region/Gene «
Variant type:
+
-
SNP (375)
Locus (3)
Haplotype (53)
Other (1)
STR (11)
Deletion (5)
CNV (1)
(1)
VNTR (1)
Variant effect:
+
-
Longevity‑Associated (344)
No Age Effect (382)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs440446
APOE
1083.00
0.509
597 vs 1275
—
Sichuan
90+
—
—
Candidate Region/Gene
24924924
rs1544410-rs17878969
VDR
15.30
0.001
104 vs 114
—
Caucasian
,
Spaniard
>85
non G-S haplotypes
G-S
Candidate Region/Gene
20407924
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
VDR
11.50
0.024
104 vs 114
—
Caucasian
,
Spaniard
>85
G-G-C-G-S
non G-G-C-G-S haplotypes
Candidate Region/Gene
20407924
APOE e2,e3,e4
APOE
9.24
0.01
224 vs 441
—
Ashkenazi Jewish
75
e4
e2
Candidate Region/Gene
15621215
rs2280789
RANTES
8.80
0.03
104 vs 110
—
Spaniard
Mean age 89.5
C
T
Candidate Region/Gene
22265023
–11391 G/A
ADIPOQ10
8.48
0.026
148 vs 414
—
Polish
Mean age 101.1 +/- 1.2
G
A
Candidate Region/Gene
23339001
1376G/T;1388G/A;95A/G;871G/A;1024C/T;1360C/T;392 G/T
G6PD
6.30
0.013
173 total (see notes)
—
Chinese
>80
—
—
Candidate Region/Gene
17077204
rs1801133
MTHFR
6.00
0.014
224 vs 441
—
Ashkenazi Jewish
75
T
C
Candidate Region/Gene
15621215
KL-VS
KLOTHO
5.88
0.004
216 vs 309
—
Ashkenazi Jewish
95 years and over
homozygous
—
Candidate Region/Gene
15677572
rs2107538-rs2280789
RANTES
4.90
0.03
104 vs 110
—
Spaniard
Mean age 89.6
non A-T haplotypes
A-T
Candidate Region/Gene
22265023
rs1061581-rs1043618-rs2227956
—
4.51
0.016
191 vs 53
—
Chinese
>90
non A-G-C or non A-C-T haplotypes
A-C-T
Candidate Region/Gene
19840767
APOE e2/e3/e4
APOE
4.40
0.02
179
—
Finn
Minimum age 104
e3, e4
e2
Candidate Region/Gene
11213279
rs6166
FSHR
4.21
0.036
114 vs 173
—
Italian
>/=90
Asn
Ser
Candidate Region/Gene
22985084
rs1008438
HSPA1A
3.86
0.016
168 cases
—
Danish
Mean age 92.8 +/- 0.4
А
—
Candidate Region/Gene
20388090
rs28940577
MEFV
3.70
0.004
68 vs 196 vs 121
—
Human
Minimum age 99
G
A
Candidate Region/Gene
16387839
rs422858
AGTR1
3.57
0.007
173 vs 376
—
Italian
99-106 (mean 100.9±1.7)
AG
CC
Candidate Region/Gene
22569962
rs275653
AGTR1
3.57
0.007
173 vs 376
598 vs 422
Italian
99-106 (mean 100.9±1.7)
A
G
Candidate Region/Gene
22569962
rs5882
CETP
3.56
0.001
213 vs 258
—
Ashkenazi Jewish
98,2 +/- 5,3
non-GG
GG
Candidate Region/Gene
14559957
K153R
MSTN
3.48
0.001
156 vs 384
79 vs 316
Italian
,
Spaniard
100–111
K
—
Candidate Region/Gene
23354683
K153R
MSTN
3.48
0.001
156 vs 384
79 vs 316 (unelated Italian cohort)
Spaniard
Range : 100-111
K
R
Candidate Region/Gene
23354683
rs1061581-rs1043618-rs2227956
—
3.46
0.025
191 vs 53
—
Chinese
>90
non A-G-C or non A-C-T haplotypes
A-G-C
Candidate Region/Gene
19840767
REN polymorphism - mtDNA
mtDNA
3.27
0.006
157
—
Italian
100+
—
REN10 - mtDNA haplogroup H
Candidate Region/Gene
11938442
APOE polymorphism
APOE
3.26
0.001
64 vs 1344
—
Italian
100+
e4
e2
Candidate Region/Gene
16960022
rs2701858, rs9486902
—
3.23
0.0001
1088
—
Danish
92+
—
—
Candidate Region/Gene
23607278
rs2107538
RANTES
3.20
0.029
104 vs 110
—
Spaniard
Mean age 89.4
A
G
Candidate Region/Gene
22265023
Page 1 of 32
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25 of 784 variants
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