Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+ (very old), 73-91 (old) G C Candidate Region/Gene 23125046
rs1800896 IL10 3.10 0.0003 142 vs 153 — Mean age 67 AA GG Candidate Region/Gene 15466015
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
Met410Val SHC1 — 0.192 730 563 Human 85+ Met — Candidate Region/Gene 15036421
rs1887922 IDE 2.02 0.0004 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
rs2251101 IDE 1.88 0.0011 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
2437 T>C HSPA1L — 0.01 129 vs 100 — Irish 80–97 2437C — Candidate Region/Gene 12742533
rs4646994 ACE — 0.04 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals — Chinese Old: 59-70, Very old 90-113 I (insertion) — Candidate Region/Gene 11773214
FOXO3A, various FOXO3 1.67 0.0002 760 vs 1060 — Chinese 100+ — — Candidate Region/Gene 20884733
rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
rs2542052 APOC3 — 0.0001 213 old vs 216 offspring vs 258 controls — Ashkenazi Jewish 100+ A — Candidate Region/Gene 16602826
APOE polymorphism APOE 3.26 0.001 64 vs 1344 — Italian 100+ e4 e2 Candidate Region/Gene 16960022
HUMTHO1.STR TH 0.85 0.005 210 vs 755 — Italian 100+ — 10* (imperfect allele 10) Candidate Region/Gene 12297342
rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
rs1333049 — 0.64 0.001 80 (cases) vs 258 healthy young — Human 100–104 C — Candidate Region/Gene 20230275
rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
rs5882 CETP — 0.318 175 vs 189 — Italian 99.6 — — Candidate Region/Gene 15888337
(+)2019 del ADIPOQ10 — 0.05 118 centenarians vs 78 unrelated young — Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
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  • 25 of 784 variants