Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
MTP -493G/T MTP — 0.854 — — Chinese — — — - 23273182
STR variation CSF1TPO — 0.003 60 vs 250 — Chinese >90 low variation in STRs high variation in STRs - 20582731
9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 — Chinese 90-100 years old J non-J - 18759861
5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
rs4746720 — 1.35 0.022 246 vs 236 — Chinese 60-90 — C Candidate Region/Gene 20633545
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
mt5178A ND2 — 0.05 95 vs 105 — Chinese Mean age 76 — АА Candidate Region/Gene 12384792
rs189037 (genotype) ATM — 0.004 875 (280 m, 595 f) vs 886 (491 m, 395 f) — Chinese Mean age 94,6, healthy — CT (Article); GA (ENSEMBL) Candidate Region/Gene 20816691
VNTR DC-SIGNR — 0.041 361 vs 342 — Chinese >90 non-6/7 genotype 6/7 genotype Candidate Region/Gene 20003397
rs189037 ATM — 0.004 875 vs 886 — Chinese mean 94.6 — CT Candidate Region/Gene 20816691
microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 — 0.922 493 vs 425 — Chinese (females ≥ 94; males ≥ 90 — — Candidate Region/Gene 20199671
rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
rs2288377 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs5742612 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs35767 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs17630266 FOXO1 — 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 — — Candidate Region/Gene 19793722
rs2755209 FOXO1 0.80 0.0046 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
rs2755213 FOXO1 0.75 7.4e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
rs2253310 FOXO3 1.35 7.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C G Candidate Region/Gene 19793722
rs2802292 FOXO3 1.36 2.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 G T Candidate Region/Gene 19793722
rs4946936 FOXO3 1.40 1.8e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 T C Candidate Region/Gene 19793722
rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
rs4746720 SIRT1 1.35 0.022 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
FOXO3A, various FOXO3 1.67 0.0002 760 vs 1060 — Chinese 100+ — — Candidate Region/Gene 20884733
rs4646994 ACE — 0.849 399 vs 302 — Chinese >90 years — — Candidate Region/Gene 19502260
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  • 25 of 104 variants