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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
rs5882 CETP 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
rs2866164 MTP 0.05 205 vs 288 Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
Ile119Val PCMT1 0.049 40 vs 40 Ashkenazi Jewish Mean age 87.2 Candidate Region/Gene 10496068
rs2866164 MTTP 0.05 126 vs 288 Ashkenazi Jewish median age = 97 CG/GG Candidate Region/Gene 22496539
rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish mean age 98.2 A Candidate Region/Gene 16602826
rs2542052 APOC3 0.001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
KL-VS KLOTHO 5.88 0.004 216 vs 309 Ashkenazi Jewish 95 years and over homozygous Candidate Region/Gene 15677572
rs1801133 MTHFR 0.029 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 C Candidate Region/Gene 15621215
rs9536314 KL 0.007 216 vs 309 Ashkenazi Jewish >95 TG (genotype) Candidate Region/Gene 15677572
rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
A/G IGF2 0.063 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 A, AA Candidate Region/Gene 15621215
rs5882 CETP 0.05 300 vs 320 vs 258 Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
APOE e2,e3,e4 APOE 9.24 0.01 224 vs 441 Ashkenazi Jewish 75 e4 e2 Candidate Region/Gene 15621215
CTSD CTSD 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
ApaI IGF2 0.063 224 vs 441 Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
rs4880 SOD2 0.009 224 vs 441 Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
rs1801133 MTHFR 6.00 0.014 224 vs 441 Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
R353Q F7 0.045 224 vs 441 Ashkenazi Jewish 75 A G Candidate Region/Gene 15621215
AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
TP53 TP53 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
DRD4 DRD4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
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  • 25 of 38 variants