| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| REN polymorphism - mtDNA | mtDNA | 3.27 | 0.006 | 157 | — | Italian | 100+ | — | REN10 - mtDNA haplogroup H | Candidate Region/Gene | 11938442 |
| rs915179-rs2485662-rs4641-rs1468772 | LMNA | 1.56 | 2.5e-05 | 873 vs 443 | New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) | American, Caucasian | Mean age 101.5 | — | GTCT | Candidate Region/Gene | 22340368 |
| rs1800896 - rs1800629 | IL10 | — | 0.038 | 174 vs 224 | — | Italian | >100 | — | GG-GG (only in men) | Candidate Region/Gene | 12676903 |
| rs1800591-rs61733139 | MTTP | — | 0.61 | 197 vs 251 | — | Dutch | Mean age 93.8±3.1 | — | — | Candidate Region/Gene | 16611701 |
| rs1800591-rs61733139 | MTTP | — | 0.46 | 655 vs 244 | — | Dutch | Mean age 87.5±3.1 | — | — | Meta-Analysis | 16611701 |
| HP*1 F/S | HP | 0.82 | 0.33 | 1072 total | — | Italian | >88 | — | — | Candidate Region/Gene | 21147083 |
| rs2234693 - rs2234693 | ESR1 | — | 0.12 | 108 vs 85 | — | Italian | 90+ | — | — | Candidate Region/Gene | 20819792 |
| APOE polymorphism | APOE | — | 0.437 | 1408 cases | — | Brazilian | 69.3 +/- 7.2 | — | — | Candidate Region/Gene | 17934638 |
| rs11279109 - APOB XbaI | APOB | — | 0.001 | 191 (case) vs 53 (initial) | — | Chinese | > 90 baseline, Mean age 97 +/- 3 | — | D - X+ | Candidate Region/Gene | 17393087 |
| rs1061581 - rs1008438 - rs2227956 | Hsp70Ba | 0.55 | 0.015 | 168 cases | — | Danish | Mean age 92.8 +/- 0.4 | — | G-C-T (haplotype) | Candidate Region/Gene | 20388090 |
| HP1/2 common polymorphism | HP | — | 0.05 | 200 (cases) vs 539 (initial) (initial) | — | Italian | >88 | — | — | Candidate Region/Gene | 21703254 |
| Haplogroup J | — | 0.38 | 0.025 | 98 vs 117 | — | Chinese | 90–100 | — | — | Candidate Region/Gene | 18759861 |
| 5178A,10400T | mtDNA | — | 0.387 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 3010A,5178A,10400T | mtDNA | — | 0.141 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 14979C,3010A,5178A,10400T | mtDNA | — | 0.781 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 8020A,3010A,5178A,10400T | mtDNA | — | 0.549 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 8964T,8020A,3010A,5178A,10400T | mtDNA | — | 0.319 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 9296T,8964T,8020A,3010A,5178A,10400T | mtDNA | — | 0.55 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 1107C,5178A,10400T | mtDNA | — | 0.559 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 14569A,10400T | mtDNA | — | 0.796 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 4833G,14569A,10400T | mtDNA | — | 0.949 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 7600A,4833G,14569A,10400T | mtDNA | — | 0.153 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 9824C,10400T | mtDNA | — | 0.955 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 12811C,9824C,10400T | mtDNA | — | 0.587 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
| 7196A,10400T | mtDNA | — | 0.847 | 463 vs 1389 | — | Chinese | >/=95 | — | — | Mitochondrial Haplogroup | 19641616 |
