Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
rs1801133 MTHFR — 0.029 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — C Candidate Region/Gene 15621215
rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
rs2229765 IGF-1 — 0.04 222 vs 288 — Italian >85 G A Candidate Region/Gene 19460140
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs1800591 MTTP — 0.64 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs61733139 MTTP — 0.43 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs1800591 MTTP — 0.6 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs61733139 MTTP — 0.57 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
rs4952085 XDH 1.25 0.000933537 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
rs12050077 TSHR 1.32 0.01 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
rs10149689 TSHR 1.22 0.08 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
rs2338013 — 0.67 2.07e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs350450 — 0.69 6.34e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs29228 — 0.68 9.12e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs3129063 — 0.67 4.33e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
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  • 25 of 572 variants