| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| rs2229765 | IGF-1 | — | 0.04 | 222 vs 288 | — | Italian | >85 | G | A | Candidate Region/Gene | 19460140 |
| rs1800795 | IL-6 | — | 0.007 | 323 (cases) vs 377 (initial) | — | Italian | median age = 101 | G | C | Candidate Region/Gene | 11500818 |
| rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
| rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
| rs28969505 | YTHDF2 | — | 0.047 | 136 vs 275 | — | Italian | Mean age 101 | — | 15-15 (205 bp) | Candidate Region/Gene | 16799135 |
| rs2802288 | FOXO3A | 1.51 | 0.003 | 281 vs 195 | — | Italian | 90–108 | G | A | Candidate Region/Gene | 19415983 |
| CHIT1 24-bp duplication | CHIT1 | — | 0.05 | 129 vs 129 | 29 versus 129 | Tunisian, Greek, Italian | Mean age 97.6 | Absence of duplication | Presence of duplication | Candidate Region/Gene | 19881466 |
| ASP299GLY | TLR4 | — | 0.04 | 8 vs 8 | — | Italian | 25-50 | — | — | — | 16803999 |
| HUMTHO1 (STR) | THO | — | 0.05 | 196 (143 f, 53 m) vs 358 (296 f; 64 m) | — | Italian | >100 | 9-10 (long alleles, homozygous genotype) | — | Candidate Region/Gene | 9887369 |
| Not specified | REN | — | 0.029 | 157 vs 218 | — | Italian | Centenarians | 11 | — | Candidate Region/Gene | 15105583 |
| APOA1-MspI-RFLP A/P alleles | APOA1 | — | 0.045 | 413 vs. 571 | — | Italian | median age 101 | A | P | Candidate Region/Gene | 12556235 |
| HinfI347 | APOA4 | — | 0.05 | 71 vs 100 | — | Italian | mean102.3 years | — | — | Candidate Region/Gene | 9622284 |
| rs675 | APOA4 | — | 0.05 | 58 vs 100 | — | Italian | Mean age 102,3 | — | A (NCBI) | Candidate Region/Gene | 9622284 |
| VNTR (Variable Number of Tandem Repeats) | APOB | — | 0.003 | 143 vs 158 | — | Italian | mean age is 102 years | 35 or more tandem repeats | — | Candidate Region/Gene | 9050915 |
| S61712.1 (GenBank, 3` VNTR) | — | — | 0.003 | 143 (51 m, 92 f) vs 158 (77 m, 81 f) | — | Italian | 102 +/- 2 | <35 repeats | — | Candidate Region/Gene | 9050915 |
| GSTT1 deletion | GSTT1 | — | 0.03 | 94 vs 418 | — | Italian | Mean age 100.2 | Not homozygous for d | Homozygous for delet | Candidate Region/Gene | 11162685 |
| - | GSTM1 | — | 0.74 | 94 vs 418 | — | Italian | 100 years vs 46 years | — | — | - | 11162685 |
| - | CYP1A | — | 0.68 | 94 vs 418 | — | Italian | 100 years vs 46 years | — | — | Candidate Region/Gene | 11162685 |
| (A/C)−110 | HSP70-1 | 0.40 | 0.005 | 120 vs 471 | — | Italian | 100 years and above | A | — | Candidate Region/Gene | 14501185 |
| rs2430561 | IFNG | — | 0.02 | 174 vs 248 | — | Italian | >99 | T (females) | — | Candidate Region/Gene | 11772518 |
| rs2229765 | IGF1R | — | 0.03 | 218 vs 278 | — | Italian | 98 | — | AA or AG | Candidate Region/Gene | 12843179 |
| −1082 G/A | IL10 | — | 0.025 | 190 vs 260 | — | Italian | >99 years old | — | G | Candidate Region/Gene | 11857058 |
| rs1800471 | TGFB1 | — | 0.034 | 172 vs 247 | — | Italian | 90-103 | GC (genotype) | — | Candidate Region/Gene | 15569360 |
| rs1042522 | TP53 | 0.57 | 0.006 | 100 very old vs 280 old vs 189 young | — | Italian | 91+ (very old), 73-91 (old) | G | C | Candidate Region/Gene | 23125046 |
| rs1042522 | TP53 | — | 0.006 | 503 vs 569 | — | Italian | >81 | R | — | Candidate Region/Gene | 23125046 |
