Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — — 9425225
rs1801133 MTHFR — 0.06 564 vs. 374 — French mean age 100.71 TT CT, CC Candidate Region/Gene 9106548
CYP2D6*3 CYP2D6 — 1.0 552 vs 243 — French mean 101 — — Candidate Region/Gene 9654200
CYP2D6*4 CYP2D6 — 1.0 523 vs 252 — French mean 101 — — Candidate Region/Gene 9654200
GSTM1 deletion GSTM1 — 1.0 565 vs 229 — French mean 101 — — Candidate Region/Gene 9654200
NAT2*5A (C 481 T), NAT2*6A (G 590 A), NAT2*7A (G 857 A), and NAT2*14A (G 191 A) NAT2 — 1.0 188 vs 88 — French mean 101 — — Candidate Region/Gene 9654200
- HRAS1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes — — - 19367319
- SIRT3 — 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- TH — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- INS — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- IGF2 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs4073591 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs4073590 DEAF1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs11040489 KRTAP5-6 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs4930001 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs800140 TSPAN32 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
rs16928120 — — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
DR7 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
DR11 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
DR13 HLA-DRB1 — 0.01 325 centenarians versus 229 nonagenarian siblings — French — — — - 9425225
apoAIV(360:His) APOA4 — 0.005 119 (see notes) vs 264 — French 74.29 ∓ 8.46 ApoAIV-1_x000D_, by the order of the sentence - I'm assuming it's Glutamine = G — Candidate Region/Gene 9533408
I/D (insertion/deletion) ACE — 0.33 560 vs 560 — French centenarians 100th year or beyond, mean age 103.1 — — Candidate Region/Gene 11280044
rs1799752 ACE — 0.025 394 vs 238 — French 100.6 years Insertion — Candidate Region/Gene 9761238
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