polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs4673 | — | 1.48 | 0.022 | — | — | Russian | — | C | T | Candidate Region/Gene | 23755540 |
rs3814314 | LMNA | — | 0.017 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | American, Caucasian | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs11578696 | LMNA | — | 0.21 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs4661146 | LMNA | — | 0.12 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | American, Caucasian | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs1801133 | MTHFR | — | 0.029 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | — | C | Candidate Region/Gene | 15621215 |
rs4880 | SOD2 | — | 0.009 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | — | T | Candidate Region/Gene | 15621215 |
rs769449 | APOE | 0.70 | 0.018 | 1,089 vs 736 | 1,613 vs 1,104 | Danish, German | 92-93 Danish, 95–110 German | G | — | — | 22234866 |
rs3772190 | TERC | — | 0.006 | 1013 total | — | Danish | — | A | G | Candidate Region/Gene | 22136229 |
rs1800775 | CETP | — | 0.02 | 10261 | — | Danish | 20-93, followed for up to 34 years | CC | non-CC | Candidate Region/Gene | 23083790 |
rs708272 | CETP | — | 0.02 | 10261 | — | Danish | 20-93, followed for up to 34 years | GG | non-GG | Candidate Region/Gene | 23083790 |
rs2107538 | RANTES | 3.20 | 0.029 | 104 vs 110 | — | Spaniard | Mean age 89.4 | A | G | Candidate Region/Gene | 22265023 |
rs2280789 | RANTES | 8.80 | 0.03 | 104 vs 110 | — | Spaniard | Mean age 89.5 | C | T | Candidate Region/Gene | 22265023 |
rs9340799 | ESR1 | — | 0.22 | 108 vs 85 | — | Italian | 90+ | — | — | Candidate Region/Gene | 20819792 |
rs10047589 | TXNRD1 | 1.46 | 0.043 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | G | — | Candidate Region/Gene | 22406557 |
rs207444 | XDH | — | 0.046 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | G - Unsure | — | Candidate Region/Gene | 22406557 |
rs26802 | GHRL | 2.34 | 0.032 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | A | — | Candidate Region/Gene | 22406557 |
rs13320360 | MLH1 | 3.13 | 0.0036 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | A | — | Candidate Region/Gene | 22406557 |
rs2509049 | H2AFX | 0.63 | 0.017 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | A | — | Candidate Region/Gene | 22406557 |
rs705649 | XRCC5 | — | 0.029 | 1089 (see notes - follow-up study) | 563 (see notes - follow-up study) | Danish | 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up | A - Unsure | — | Candidate Region/Gene | 22406557 |
rs1002149 | GSR | 0.71 | 0.0335 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | C | Candidate Region/Gene | 22406557 |
rs1207362 | KL | 0.63 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | C | Candidate Region/Gene | 22406557 |
rs2267723 | GHRHR | 0.70 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | G | A | Candidate Region/Gene | 22406557 |
rs3842755 | INS | 1.79 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | C | A | Candidate Region/Gene | 22406557 |
rs572169 | GHSR | 0.72 | 0.0045 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | G | Candidate Region/Gene | 22406557 |
rs9456497 | IGF2R | 1.42 | 0.005 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | G | Candidate Region/Gene | 22406557 |