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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
African European (1)
Australian (3)
Canadian (1)
Finn (16)
Georgian (4)
Human (4)
Multiethnic (19)
Sichuan (18)
Spanish (4)
American (303)
African American (2)
Amish (2)
Mexican (1)
Nigerian (1)
Tunisian (1)
Turkish (6)
Asian (1)
Chinese (104)
Japanese (61)
Okinawan (4)
Korean (17)
Brazilian (2)
Caucasian (388)
European (10)
British (61)
Polish (15)
Croatian (1)
Danish (88)
Dutch (87)
French (34)
German (134)
Greek (9)
Irish (16)
Italian (263)
Calabrian (1)
Calabrian (8)
Northern European (19)
Scottish (2)
Bulgarian (7)
Swiss (1)
Spaniard (12)
Hispanic (1)
Ashkenazi Jewish (38)
Jordanian (8)
Russian (4)
Tatar (1)
Study type:
+
-
GWAS (2)
‑ (27)
Candidate Region/Gene (784)
Meta‑Analysis (38)
Complete Mitochondrial Genome (2)
Whole‑Genome Linkage Scan (1)
Genome‑Wide Association Study (710)
Mitochondrial Haplogroup (36)
Mitochondrial genome (3)
Variant type:
+
-
SNP (572)
Locus (5)
Haplotype (87)
Other (1)
STR (11)
Deletion (5)
CNV (1)
(1)
VNTR (1)
Variant effect:
+
-
Longevity‑Associated (1027)
No Age Effect (543)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
KIR2DS3 haplotypes
KIR2DS3
—
0.05
100 vs 100
—
Irish
Age range: 65-99
—
—
Candidate Region/Gene
21299522
rs3772190
TERC
—
0.006
1013 total
—
Danish
—
A
G
Candidate Region/Gene
22136229
rs12696304
TERC
—
0.248
1013 total
—
Danish
—
—
—
Candidate Region/Gene
22136229
ACE genotype
ACE
—
0.716
102 vs 7232
—
Korean
Mean age 102
—
—
Candidate Region/Gene
12634288
rs1800775
CETP
—
0.02
10261
—
Danish
20-93, followed for up to 34 years
CC
non-CC
Candidate Region/Gene
23083790
rs708272
CETP
—
0.02
10261
—
Danish
20-93, followed for up to 34 years
GG
non-GG
Candidate Region/Gene
23083790
rs2060793
CYP2R1
—
0.04
1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners)
—
Dutch
Males: >/= 89; Females: >/= 91
—
—
Candidate Region/Gene
23128285
rs2060793
CYP2R1
—
0.04
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
A
—
Candidate Region/Gene
23128285
rs2282679
GC
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs3829251
NADSYN1
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs2107538
RANTES
3.20
0.029
104 vs 110
—
Spaniard
Mean age 89.4
A
G
Candidate Region/Gene
22265023
rs2280789
RANTES
8.80
0.03
104 vs 110
—
Spaniard
Mean age 89.5
C
T
Candidate Region/Gene
22265023
rs2107538-rs2280789
RANTES
—
0.04
104 vs 110
—
Spaniard
Mean age 89.6
non G-C haplotypes
G-C
Candidate Region/Gene
22265023
rs2107538-rs2280789
RANTES
4.90
0.03
104 vs 110
—
Spaniard
Mean age 89.6
non A-T haplotypes
A-T
Candidate Region/Gene
22265023
rs1544410-rs17878969
VDR
15.30
0.001
104 vs 114
—
Caucasian
,
Spaniard
>85
non G-S haplotypes
G-S
Candidate Region/Gene
20407924
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
VDR
11.50
0.024
104 vs 114
—
Caucasian
,
Spaniard
>85
G-G-C-G-S
non G-G-C-G-S haplotypes
Candidate Region/Gene
20407924
APOE4
APOE
—
0.71
106 vs 349
—
American
70-79 (duration of study - 7 years)
e4
—
Candidate Region/Gene
16799145
rs1937
TFAM
—
0.003
107 vs 284
—
Spaniard
100–111
G
CC (genotype)
Candidate Region/Gene
23186209
HP 1/2
HP
1.27
0.0194
1072 total
—
Italian
>88
HP*2
HP*1
Candidate Region/Gene
21147083
HP*1 F/S
HP
0.82
0.33
1072 total
—
Italian
>88
—
—
Candidate Region/Gene
21147083
rs1801133
MTHFR
—
0.01
108 (patients with CVD) vs 118
—
Swiss
>65
C
—
Candidate Region/Gene
10583447
HMOX1 (GT)_n repeats
HMOX1
0.56
0.0027
108 vs 154
—
Japanese
Mean age 80.5
33 < repeats
—
Candidate Region/Gene
12566526
rs4646
CYP19
1.90
0.04
108 vs 85
—
Italian
90+
—
T
Candidate Region/Gene
20819792
rs2234693
ESR1
—
0.08
108 vs 85
—
Italian
90+
PP (genotype)
—
Candidate Region/Gene
20819792
rs2234693 - rs2234693
ESR1
—
0.12
108 vs 85
—
Italian
90+
—
—
Candidate Region/Gene
20819792
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25 of 1635 variants
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