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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Dutch «
Danish (2)
French (1)
German (1)
Italian (1)
Tatar (1)
Study type:
+
-
Candidate Region/Gene (16)
Meta‑Analysis (3)
Genome‑Wide Association Study (67)
Variant type:
+
-
SNP (15)
Haplotype (4)
Variant effect:
+
-
Longevity‑Associated (70)
No Age Effect (14)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs662
PON1
1.06
0.11
—
—
Danish
,
Dutch
,
French
,
German
,
Italian
,
Tatar
>/=80
—
—
Candidate Region/Gene
20362697
Cdx2-GATA haplotype 1 allele
Vitamin D receptor
—
0.78
935 participants
—
Dutch
mean age = 75.7 years
—
—
Candidate Region/Gene
21051524
rs2069827
IL6
—
0.064
1,089 vs 736
563 (longtitudinal study)
Danish
,
Dutch
92+ Danish, 85+ Dutch
A
—
—
22234866
rs2060793
CYP2R1
—
0.04
1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners)
—
Dutch
Males: >/= 89; Females: >/= 91
—
—
Candidate Region/Gene
23128285
rs2060793
CYP2R1
—
0.04
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
A
—
Candidate Region/Gene
23128285
rs3829251
NADSYN1
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs2282679
GC
—
0.6
1038 vs 461
—
Dutch
59.5 years (offspring of nonagerians)
—
—
Candidate Region/Gene
23128285
rs12778366
SIRT1
0.69
0.025
1390
—
Dutch
36 to 79
—
—
Candidate Region/Gene
23505545
rs1800591-rs61733139
MTTP
—
0.93
164 vs 261
—
Dutch
Mean age 93.8 ± 3.1
—
—
Candidate Region/Gene
16611701
rs1800591-rs61733139
MTTP
—
0.61
197 vs 251
—
Dutch
Mean age 93.8±3.1
—
—
Candidate Region/Gene
16611701
rs970048
Intergenic
1.77
7.17e-07
3746 vs 5912
—
Dutch
Mean age 94
—
G
Genome-Wide Association Study
21418511
rs61733139
MTTP
—
0.57
379 vs 251
—
Dutch
Mean age 93.8 ± 3.1
—
—
Candidate Region/Gene
16611701
rs1800591
MTTP
—
0.6
379 vs 251
—
Dutch
Mean age 93.8 ± 3.1
—
—
Candidate Region/Gene
16611701
rs970048
Intergenic
1.77
7.17e-07
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
G
Genome-Wide Association Study
21418511
rs2075650
TOMM40
0.53
2.65e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
G
—
Genome-Wide Association Study
21418511
rs1893132
Intergenic
2.07
3.19e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
A
Genome-Wide Association Study
21418511
rs4110518
Intergenic
1.52
3.26e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
A
Genome-Wide Association Study
21418511
rs9827142
Intergenic
1.49
4.88e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
C
Genome-Wide Association Study
21418511
rs10490478
Intergenic
1.63
5.79e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
G
Genome-Wide Association Study
21418511
rs9868286
CCDC50
1.48
7.4e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
C
Genome-Wide Association Study
21418511
rs11122430
Intergenic
1.50
7.65e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
A
Genome-Wide Association Study
21418511
rs12548622
Intergenic
0.54
8.78e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
G
—
Genome-Wide Association Study
21418511
rs2290889
SYK
2.00
9.14e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
A
Genome-Wide Association Study
21418511
rs4736209
Intergenic
0.64
9.5e-06
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
G
—
Genome-Wide Association Study
21418511
rs7864625
SYK
2.00
1.01e-05
403 vs 1670
3746 vs 5912
Dutch
Mean age 94
—
G
Genome-Wide Association Study
21418511
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25 of 87 variants
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