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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs662 PON1 1.06 0.11 Danish, Dutch, French, German, Italian, Tatar >/=80 Candidate Region/Gene 20362697
NAT2*5A (C 481 T), NAT2*6A (G 590 A), NAT2*7A (G 857 A), and NAT2*14A (G 191 A) NAT2 1.0 188 vs 88 French mean 101 Candidate Region/Gene 9654200
- PARP1 1.0 239 vs 198 French >100 Candidate Region/Gene 9587069
CYP2D6*4 CYP2D6 1.0 523 vs 252 French mean 101 Candidate Region/Gene 9654200
CYP2D6*3 CYP2D6 1.0 552 vs 243 French mean 101 Candidate Region/Gene 9654200
I/D (insertion/deletion) ACE 0.33 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 Candidate Region/Gene 11280044
GSTM1 deletion GSTM1 1.0 565 vs 229 French mean 101 Candidate Region/Gene 9654200
- HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
- SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073591 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4930001 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs800140 TSPAN32 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs16928120 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
  • 18 variants