Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
rs1054016 TNFSF11 1.09 0.579 137 vs 213 — Korean Mean age 90 T — Genome-Wide Association Study 19641380
(rs429358, rs7412) + (rs2075650) APOE + TOMM40 0.93 0.337 403 vs 1670 3746 vs 5912 Dutch Mean age 94 e4 + G — Genome-Wide Association Study 21418511
rs1800802 MGP 0.77 0.132 137 vs 213 — Korean Mean age 90 C — Genome-Wide Association Study 19641380
rs2274471 JAK2 (for males) 1.58 0.088 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
9q31.3–34.2 — — 0.054 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
3p24.2–22.3 — — 0.037 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
rs6459623 IBRDC2 — 0.00015 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs1405051 — — 0.00014 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs1915501 — — 0.00011 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs712773 GRM7 0.66 9.99e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs731287 — 2.51 9.88e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs4594173 MADMC1 1.94 9.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs81647 — 0.58 9.77e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs3134204 — 1.51 9.71e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs2111173 PTPRO 1.74 9.24e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs3102484 — 1.82 9.2e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs6540664 — 1.46 9e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs697739 ATXN1 0.59 8.97e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs9366292 — 0.64 8.65e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs135416 — 0.57 8.65e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs1584547 — 2.96 8.52e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs4505466 SH3BP4 2.06 8.31e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs10498263 OR4Q3 — 8.3e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs2073586 ABCC8 0.48 8.15e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
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  • 25 of 103 variants