Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs662 PON1 — 1.0 579 vs 308 — Italian Over 100 G A Candidate Region/Gene 12082503
rs854560 PON1 — 1.0 579 vs 308 — Italian Over 100 — — Candidate Region/Gene 12082503
rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
CYP2D6*3 CYP2D6 — 1.0 552 vs 243 — French mean 101 — — Candidate Region/Gene 9654200
CYP2D6*4 CYP2D6 — 1.0 523 vs 252 — French mean 101 — — Candidate Region/Gene 9654200
GSTM1 deletion GSTM1 — 1.0 565 vs 229 — French mean 101 — — Candidate Region/Gene 9654200
NAT2*5A (C 481 T), NAT2*6A (G 590 A), NAT2*7A (G 857 A), and NAT2*14A (G 191 A) NAT2 — 1.0 188 vs 88 — French mean 101 — — Candidate Region/Gene 9654200
- PARP1 — 1.0 239 vs 198 — French >100 — — Candidate Region/Gene 9587069
codon 192 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
codon 55 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
11 different snps tested, not all given. MTTP — 1.0 1398 vs 777 — British 77.9 ± 0.2 — — Candidate Region/Gene 17339647
length (STR polymorphism) TH — 1.0 196 vs 358 471 vs 462 German (in replication) 96-110 years — — Candidate Region/Gene 21407269
(HLA)-A1, B8, DR3 — — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs1800629 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs909253 TNF — 1.0 93 vs 100 — Irish 80-97 years — — Candidate Region/Gene 12714268
rs2288377 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs5742612 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs35767 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs17630266 FOXO1 — 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 — — Candidate Region/Gene 19793722
rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
rs1799814 CYP1A1 1.16 1.0 205 vs 294 — German 80-89; reference group: 17-79 — — - 15177664
rs5182 AGTR1 0.97 1.0 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
rs5183 AGTR1 0.27 1.0 173 vs 376 — Italian 99-106 (mean 100.9±1.7) — — Candidate Region/Gene 22569962
rs2153960 FOXO3A — 1.0 1435 vs 2098 — Multiethnic 90+ — — Meta-Analysis 25038186