Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs5882 CETP — 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
rs2297518 NOS2 — 0.066 321 vs 442 — Italian 89-107 — — Candidate Region/Gene 23572278
rs12200646 FOXO3 1.28 0.064 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
A/G IGF2 — 0.063 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — A, AA Candidate Region/Gene 15621215
ApaI IGF2 — 0.063 224 vs 441 — Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
rs1801133 MTHFR — 0.06 564 vs. 374 — French mean age 100.71 TT CT, CC Candidate Region/Gene 9106548
12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
rs2485662 LMNA — 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 — — Candidate Region/Gene 22340368
rs1468772 LMNA 1.17 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
IL6 VNTR A/B/C/D — 0.56 0.05 61 vs 94 — Italian Mean age 100 B non-B Candidate Region/Gene 17506774
rs2866164 MTP — 0.05 205 vs 288 — Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
IL10 haplotypes IL10 — 0.05 60 vs 60 — Bulgarian Age range: 65-99 — −1082G, −819C, -592C Candidate Region/Gene 21299522
IL10 haplotypes IL10 — 0.05 237 vs 90 — Turkish Age range: 65-99 — −1082G, −819C, −592C Candidate Region/Gene 21299522
TGFB1 haplotypes TGFB1 — 0.05 297 vs 130 — Turkish, Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G — Candidate Region/Gene 21299522
TGFB1 haplotypes TGFB1 — 0.05 60 vs 40 — Bulgarian Age range: 65-99 codon 10 C/C, codon 25 G/G; −988 C/C, −800 G/G — Candidate Region/Gene 21299522
KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
rs3781907 UCP3 — 0.05 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) — Danish 93 G — Candidate Region/Gene 22743239
HinfI347 APOA4 — 0.05 71 vs 100 — Italian mean102.3 years — — Candidate Region/Gene 9622284
rs2866164 MTTP — 0.05 126 vs 288 — Ashkenazi Jewish median age = 97 CG/GG — Candidate Region/Gene 22496539
APOC3 T455C APOC3 — 0.05 147 elderly individuals (70–106 years old) — Russian mean age: 84.6 years — — Candidate Region/Gene 11193221
Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
Cdx2–GATA haplotypes VDR — 0.05 923 — Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
rs675 APOA4 — 0.05 58 vs 100 — Italian Mean age 102,3 — A (NCBI) Candidate Region/Gene 9622284
rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216